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New Research In Nature Has Found That Mannose Can Fight Cancer-from Sanyuan Longsheng
Dec 21, 2018

《自然》最新研究发现甘露糖可以抗癌,而D甘露糖产业市值已达千万美元New research in Nature has found that mannose can fight cancer, and the market value of D-mannose industry has reached tens of millions of dollars.

服用单糖甘露糖可以减缓小鼠的肿瘤生长

Monosaccharide mannose inhibits tumor growth in mice

根据英国《自然》近日在线发表的一篇肿瘤学论文,单独或结合化疗药物服用单糖甘露糖可以减缓小鼠的肿瘤生长。这项研究被认为前景可观,但目前仍需要进一步的研究加以验证

Monosaccharide mannose alone or in combination with chemotherapeutic drugs can slow down the growth of tumors in mice, according to an oncology paper published online recently in Nature. This study is considered promising, but further research is still needed to verify it.

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许多肿瘤会经历代谢变化,表现出葡萄糖摄取增加,由此引出了一个问题:服用不同类型的糖,是否能够影响肿瘤的生长?

Many tumors undergo metabolic changes, showing increased glucose uptake, which raises the question: Can taking different types of sugar affect the growth of tumors?

鉴于此,英国癌症研究中心科学家凯文·莱恩及其同事,在最新实验中研究了甘露糖对肿瘤细胞生长的影响。他们报告称,甘露糖减缓了肿瘤细胞生长,并提出甘露糖或许能够干涉葡萄糖代谢。此外,结合化疗药物顺铂或阿霉素服用甘露糖,显著加剧了细胞死亡。

In view of this, Kevin Lane, a scientist at Cancer Research UK, and his colleagues studied the effect of Mannose on the growth of cancer cells in a new experiment. They report that mannose slows down the growth of cancer cells and suggest that mannose may interfere with glucose metabolism. In addition, the combination of cisplatin or doxorubicin with mannose significantly increased cell death.

研究人员通过饲管(一周三次)和饮水(持续性地)让肿瘤小鼠服用甘露糖。结果显示,这种疗法耐受良好,而且无论单独施用还是结合阿霉素施用,似乎都减缓了肿瘤生长。

细胞对甘露糖的敏感性与较低水平的磷酸甘露糖异构酶(PMI)相关。研究团队测试了不同人类肿瘤(卵巢癌、肾癌、乳腺癌、前列腺癌和结直肠癌)细胞中的PMI水平,结果参差不齐。尤其值得注意的是,结直肠肿瘤的PMI水平较低,这意味着它们可能对甘露糖更敏感。此外,结直肠癌小鼠服用甘露糖后,肿瘤发生明显减少。

Researchers administered mannose to tumour mice through feeding tubes (three times a week) and drinking water (continuously). The results showed that the treatment was well tolerated and seemed to slow down the growth of tumors either alone or in combination with doxorubicin.

Cell sensitivity to mannose is associated with lower levels of phosphate mannose isomerase (PMI). The team tested the levels of PMI in different human tumors (ovarian, kidney, breast, prostate and colorectal cancers) with varying results. Particularly noteworthy is the low level of PMI in colorectal tumors, which means that they may be more sensitive to mannose. In addition, the incidence of colorectal cancer in mice treated with mannose was significantly reduced.

研究人员总结表示,甘露糖疗法可能代表了一种简单而又安全的靶向多种肿瘤生长的方法。

Researchers concluded that mannose therapy may represent a simple and safe way to target the growth of multiple tumors.


蔓越莓的甘露糖含量比较丰富Cranberry is rich in mannose

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2012年到2016年,D甘露糖全球产量平均每年增长6.31

From 2012 to 2016, global production of D-mannose increased by an average of 6.31% annually.

甘露糖,是目前唯一用于在临床上的糖质营养素,广泛分布于体液和组织中,尤其是在神经、皮肤、睾丸、视网膜、肝和肠。其直接被利用合成糖蛋白,参与免疫调节。许多疾病正是由于缺乏甘露糖糖化作用中的酵素而导致的。甘露糖,通常被包装为营养补充剂“D-甘露糖

Mannose is currently the only sugar nutrient used clinically. It is widely distributed in body fluids and tissues, especially in nerves, skin, testis, retina, liver and intestine. It is directly used to synthesize glycoproteins and participate in immune regulation. Many diseases are caused by the lack of enzymes involved in mannose saccharification. Mannose is usually packaged as a nutritional supplement called D-mannose.

 D甘露糖是一种安全和天然的营养食品补充剂。它也在尿路健康保护中起重要作用。随着经济发展和社会的进步,人们不断加强健康意识,展望D甘露糖市场前景光明。根据QYResearch发布的全球D甘露糖市场研究报告2017”全球D甘露糖市场价值在2016年超过1150万美元。由于下游需求紧张,D甘露糖的市场相当稳定。 D甘露糖全球产量从2012年到2016年平均每年增长6.31%。

D mannose is a safe and natural nutritional food supplement. It also plays an important role in urinary tract health protection. With the economic development and social progress, people continue to strengthen health awareness and look forward to a bright market prospect for D mannose. According to QY Research's Global D-mannose Market Research Report 2017, the global D-mannose market value exceeded $11.5 million in 2016. Due to the tight demand downstream, the D mannose market is quite stable. Global production of D-mannose increased by an average of 6.31% annually from 2012 to 2016.

直到2016年,中国是D甘露糖的主要生产国和出口国,D-甘露糖的生产量约占总数的一半。欧洲和北美是D甘露糖的主要消费者,2016年消费市场份额约为30%。 D甘露糖行业的领先企业有Danisco(杜邦),河北华旭,Naturesupplies,道格拉斯,华昌等。丹尼斯克(杜邦)是最大的制造商。

Until 2016, China was the main producer and exporter of D-mannose, and the production of D-mannose accounted for about half of the total. Europe and North America are major consumers of D-mannose, with a market share of about 30% in 2016. Danisco (Dupont), Huaxu, Naturesupplies, Douglas, Huachang and so on are the leading companies in D mannose industry. Dennisk (DuPont) is the largest manufacturer.

未来,世界D-甘露糖消费市场仍将有一定的增长。随着经济的发展,D-甘露糖在未来具有巨大的市场潜力。由于食品添加剂需求的增加和下游产品的补充,世界D-甘露糖产能将继续扩大。

In the future, the world D-mannose consumption market will continue to grow. With the development of economy, D-mannose has great market potential in the future. Due to the increasing demand for food additives and the supplement of downstream products, world D-mannose production capacity will continue to expand.

更多的天然原料抗癌功效被发现

More natural ingredients have been found to have anti-cancer effects


抹茶可以阻止乳腺癌细胞的长大Maccha can prevent breast cancer cells from growing up

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除甘露糖之外,其他天然原料在治疗癌症方面的潜力陆续被挖掘出来。近期,一项研究发现,抹茶可以阻止乳腺癌细胞补充能量,从而杀死癌细胞。由此推断,抹茶可能具有天然治疗癌症的潜力,这项研究发表在Aging杂志上。该研究小组还发现,伯爵茶的一种成分佛手柑可以杀死癌细胞,并起到抗胆固醇的作用。

In addition to mannose, the potential of other natural raw materials in cancer treatment has been tapped. Recently, a study found that Mocha can prevent breast cancer cells from "replenishing energy" and thus kill cancer cells. It is concluded that Mocha may have the potential to treat cancer naturally, the study was published in the Aging Journal. The team also found that bergamot, a component of Earl's tea, kills cancer cells and acts as an anti-cholesterol agent.